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. 1999 Mar 22;9(6):835-40.
doi: 10.1016/s0960-894x(99)00096-7.

Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications

J S Plummer  1 , K A Berryman, C Cai, W L Cody, J DiMaio, A M Doherty, S Eaton, J J Edmunds, D R Holland, D Lafleur, S Levesque, L S Narasimhan, J R Rubin, S T Rapundalo, M A Siddiqui, A Susser, Y St-Denis, P Winocour
Affiliations

Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications

J S Plummer et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and antithrombotic activity of a series of nonpeptide bicyclic thrombin inhibitors are described. We have explored the SAR around the P1' site. Modification of the P1' site has been found to affect potency and selectivity.

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